pentobarbital will reduce the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Check.pentobarbital will lessen the extent or effect of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to